https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15067 Wed 11 Apr 2018 16:52:00 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15066 Wed 11 Apr 2018 14:58:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15068 Wed 11 Apr 2018 13:50:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9569 Wed 11 Apr 2018 13:25:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29933 15 µmol/L: OR = 2.24; 95% CI = 1.38-3.63) were independently associated with increased risk of cortical cataract. Path analysis showed that the genetic effect on cortical cataract was partially mediated via homocysteine levels. Combined CT/TT genotypes and elevated homocysteine levels were associated with a 3-fold risk of cortical cataract (OR = 3.74; 95% CI = 1.79-7.80). The synergy index of both exposures was 1.34 (95% CI = 0.44-4.01). Conclusions and Relevance: MTHFR polymorphism and elevated homocysteine levels contributed separately and jointly to increased risk of cortical cataract. If these findings are confirmed, homocysteine levels may be a therapeutic target to reduce risk of cortical cataract in persons carrying genetic risk.]]> Wed 10 Nov 2021 15:04:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8430 Sat 24 Mar 2018 08:40:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21315 P = 0.0009) but nonsignificant interactions between genetic risk status and weekly fish consumption (P = 0.05) for risk of any AMD. Among participants with high genetic risk, the highest intake tertile of LZ was associated with a >20% reduced risk of early AMD, and weekly consumption of fish was associated with a 40% reduced risk of late AMD. No similar association was evident among participants with low genetic risk. No interaction was detected between ß-carotene or vitamin C and genetic risk status. Conclusions Protection against AMD from greater LZ and fish consumption in persons with high genetic risk based on 2 major AMD genes raises the possibility of personalized preventive interventions.]]> Sat 24 Mar 2018 07:52:47 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31934 complement factor H and age-related maculopathy susceptibility 2 genes (compared with none, OR 1.76 for 1 risk allele and OR 3.34 for 2+ risk alleles), smoking (compared with non-smokers, OR 1.64 for past and OR 1.67 for current smokers), and the presence of large drusen area or retinal pigmentary abnormalities in the first eye. Conclusion: One in four to one in five unilateral any AMD cases, and up to one in two unilateral late AMD cases, progressed to bilateral in 5 years. Known AMD risk factors, including smoking, are significantly associated with the progression to bilateral involvement.]]> Mon 09 Apr 2018 11:32:09 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18788 Fri 15 May 2020 06:43:18 AEST ]]>